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77275-70-8

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77275-70-8 Structure

77275-70-8 Structure
IdentificationBack Directory
[Name]

(D-PRO2,D-PHE7,D-TRP9)-SUBSTANCE P
[CAS]

77275-70-8
[Synonyms]

(D-PRO2,D-PHE7,D-TRP9)-SUBSTANCE P
substance P, Pro(2)-Phe(7)-Trp(9)-
Substance P, (D-Pro2, D-Phe7, D-Trp9)
ARG-D-PRO-LYS-PRO-GLN-GLN-D-PHE-PHE-D-TRP-LEU-MET-NH2
(D-PROLINE2,D-PHENYLALANINE7,D-TRYPTOPHAN9)SUBSTANCE P)
H-ARG-D-PRO-LYS-PRO-GLN-GLN-D-PHE-PHE-D-TRP-LEU-MET-NH2
Substance P, 2-D-proline-7-D-phenylalanine-9-D-tryptophan-
[Molecular Formula]

C72H105N19O13S
[MDL Number]

MFCD00076807
[MOL File]

77275-70-8.mol
[Molecular Weight]

1476.79
Chemical PropertiesBack Directory
[density ]

1.42±0.1 g/cm3(Predicted)
[storage temp. ]

−20°C
[form ]

Solid
[pka]

13.27±0.46(Predicted)
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

[D-Pro2,D-Phe7,D-Trp9] Substance P is a Substance P (HY-P0201) analogue. [D-Pro2,D-Phe7,D-Trp9] Substance P is an inhibitor of Substance P. [D-Pro2,D-Phe7,D-Trp9] Substance P contracts guinea-pig ileum (GPI) indirectly[1][2].
[in vivo]

[D-Pro2,D-Phe7,D-Trp9] Substance P (1-2 mg/kg; i.v.; once) inhibits the salivary secretion which was induced by Substance P in rats. In the dosage range at 1-1.5 mg/kg slightly increases the blood pressure[2].

[References]

[1] Hawcock AB, et al. Agonist effects of [D-Pro2,D-Phe7,D-Trp9]substance P--evidence for different receptors. Eur J Pharmacol. 1982 May 7;80(1):135-8. DOI:10.1016/0014-2999(82)90189-3
[2] Folkers K, et al. Chemical design of antagonists of substance P. Acta Physiol Scand. 1981 Apr;111(4):505-6. DOI:10.1111/j.1748-1716.1981.tb06771.x
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