ChemicalBook--->CAS DataBase List--->77307-50-7

77307-50-7

77307-50-7 Structure

77307-50-7 Structure
IdentificationBack Directory
[Name]

SL0101
[CAS]

77307-50-7
[Synonyms]

SL0101
SL 0101-1
3'',4''-Di-O-acetylafzelin
Kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside)
3-(3-O,4-O-Diacetyl-α-L-rhamnopyranosyloxy)-4',5,7-trihydroxyflavone
3-[(3-O,4-O-Diacetyl-6-deoxy-α-L-mannopyranosyl)oxy]4',5,7-trihydroxyflavone
2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl 3-O,4-O-diacetyl-α-L-rhamnopyranoside
2-(4-Hydroxyphenyl)-3-(3-O,4-O-diacetyl-α-L-rhamnopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one
3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one
3-[(3,4-Di-O-acetyl-6-deoxy-α-L-Mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
[Molecular Formula]

C25H24O12
[MDL Number]

MFCD09842349
[MOL File]

77307-50-7.mol
[Molecular Weight]

516.453
Chemical PropertiesBack Directory
[Appearance]

Tan Solid
[Melting point ]

128-132°C
[Boiling point ]

753.0±60.0 °C(Predicted)
[density ]

1.57±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Acetone (Slightly), Methanol (Slightly)
[form ]

Yellow solid
[pka]

6.20±0.40(Predicted)
[color ]

Pale Yellow to Brown
Hazard InformationBack Directory
[Chemical Properties]

Tan Solid
[Uses]

A potent and selective inhibitor of p90 Rsk, without inhibiting the function of upstream kinases such as MEK, Raf, or PKC
[Biological Activity]

Selective inhibitor of p90 ribosomal S6 kinase (RSK) (IC 50 = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC.? Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.
[Description]

The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. SL 0101-1 is a kaempferol glycoside, isolated from the tropical plant F. refracta, that selectively inhibits RSK2 with an IC50 value of 89 nM (Ki = 1 μM) without interfering with upstream activators of RSK, including ERK, MEK, EGFR, and PKC. At 100 μM, SL 0101-1 inhibits the proliferation of MCF-7 breast cancer cells, arresting cells in the G1 phase of the cell cycle. SL 0101-1 has been used to characterize the intracellular signaling events associated with angiotensin II-induced tyrosine kinase activation with a concentration of 30 μM attenuating angiotensin II-induced cell proliferation.
[storage]

-20°C
Safety DataBack Directory
[HS Code ]

2940000080
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