| Identification | Back Directory | [Name]
7β,16α-Dihydroxybufalin | [CAS]
773133-78-1 | [Synonyms]
7β,16α-Dihydroxybufalin
Bufa-20,22-dienolide, 3,7,14,16-tetrahydroxy-, (3β,5β,7β,16α)- | [Molecular Formula]
C24H34O6 | [MOL File]
773133-78-1.mol | [Molecular Weight]
418.52 |
| Chemical Properties | Back Directory | [Melting point ]
293-295 °C (decomp)(Solvent: Acetone; Methanol) | [Boiling point ]
637.394±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.354±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
14.412±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
7β,16α-Dihydroxybufalin is a dihydroxylated derivative of bufalin, which exhibits cytotoxicities against cancer cell lines[1][2]. | [References]
[1] Ye M, et al. Novel cytotoxic bufadienolides derived from bufalin by microbial hydroxylation and their structure-activity relationships. J Steroid Biochem Mol Biol. 2004 Jun;91(1-2):87-98. DOI:10.1016/j.jsbmb.2004.01.010
[2] Li K, et al. Enzymatic synthesis of bufadienolide O‐glycosides as potent antitumor agents using a microbial glycosyltransferase[J]. Advanced Synthesis & Catalysis, 2017, 359(21): 3765-3772. |
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