| Identification | Back Directory | [Name]
lychnopholide | [CAS]
77448-64-7 | [Synonyms]
lychnopholide
(Z)-2-Methyl-2-butenoic acid (3aR,4S,6R,10Z,11aR)-2,3,3a,4,5,6,7,11a-octahydro-6,10-dimethyl-3-methylene-2,7-dioxo-6,9-epoxycyclodeca[b]furan-4-yl ester | [MDL Number]
MFCD29765876 | [MOL File]
77448-64-7.mol |
| Hazard Information | Back Directory | [Description]
Lychnopholide is isolated from Vanillosmopsis erythropappa. | [Uses]
Lychnopholide is a sesquiterpene lactone derived from the Asteraceae, Lychnopholide exhibits anti-trypanosomal activity against Trypanosoma cruzi. lychnopholide encapsulated in nanocapsules reduces its toxicity to mammalian cells. Lychnopholide ameliorates Chagas disease in mouse models[1]. | [References]
[1] Milagre MM, et al., Lychnopholide loaded in surface modified polylactide nanocapsules (LYC-PLA-PEG-NC) cure mice infected by Trypanosoma cruzi strain a prototype of resistance to benznidazole and nifurtimox: First insights of its mechanism of action. Exp Parasitol. 2023 Dec;255:108647. DOI:10.1016/j.exppara.2023.108647 |
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