| Identification | Back Directory | [Name]
2-[2-chloro-4-({[2-(1H-indol-3-yl)ethyl]amino}methyl)-6-methoxyphenoxy]acetamide | [CAS]
774551-07-4 | [Synonyms]
M75940037
M7594-0037
M7594 0037
M7594_0037
2-[2-chloro-4-({[2-(1H-indol-3-yl)ethyl]amino}methyl)-6-methoxyphenoxy]acetamide | [Molecular Formula]
C20H22ClN3O3 | [MOL File]
774551-07-4.mol | [Molecular Weight]
387.86 |
| Hazard Information | Back Directory | [Description]
M7594_0037 is a small molecule inhibitor of human peptide deformylase (HsPDF). HsPDF is an important target for anticancer drug discovery. M7594_0037 exhibits potent anticancer activities against HeLa, A549 and MCF-7 cell lines with IC50s of 35.26, 29.63 and 24.63 μM, respectively. | [Uses]
M7594_0037 is a potent inhibitor of human peptide deformylase (HsPDF) that has anti-tumor activity[1]. | [References]
[1] Jian Gao, et al. Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer. Molecules. 2016 Mar 23;21(4):396. DOI:10.3390/molecules21040396 |
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