| Identification | Back Directory | [Name]
AC-DNLD-CHO | [CAS]
775289-20-8 | [Synonyms]
AC-DNLD-CHO
Ac-Asp-Asn-Leu-Asp-CHO
CASPASE-3/7 INHIBITOR II
AC-ASP-ASN-LEU-ASP-H (ALDEHYDE)
Ac-Asp-Asn-Leu-Asp-aldehyde (pseudo acid)
ACETYL-L-ASPARTYL-L-ASPARAGINYL-L-LEUCYL-L-ASPART-1-AL
Caspase-3/7 Inhibitor II - CAS 775289-20-8 - Calbiochem
Caspase-3/7 Inhibitor II Ac-Asp-Asn-Leu-Asp-aldehyde (pseudo acid)
L-Leucinamide, N-acetyl-L-α-aspartyl-L-asparaginyl-N-[(1S)-2-carboxy-1-formylethyl]- | [Molecular Formula]
C20H31N5O10 | [MDL Number]
MFCD07368597 | [MOL File]
775289-20-8.mol | [Molecular Weight]
501.49 |
| Chemical Properties | Back Directory | [Boiling point ]
1034.0±65.0 °C(Predicted) | [density ]
1.349±0.06 g/cm3(Predicted) | [storage temp. ]
-20C | [solubility ]
water: 1 mg/mL || DMSO: 5 mg/mL | [form ]
White solid | [pka]
4.20±0.10(Predicted) | [color ]
white | [Water Solubility ]
water: 1mg/mL
DMSO: 5mg/mL | [Sequence]
Ac-Asp-Asn-Leu-Asp-CHO | [InChIKey]
XZGUQURUQBIHMG-XUXIUFHCSA-N | [SMILES]
N([C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C=O)C(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(=O)O)CC(=O)N |
| Hazard Information | Back Directory | [Uses]
Ac-DNLD-CHO (Ac-Asp-Asn-Leu-Asp-CHO) is a Caspase-3/7 inhibitor (IC50: 9.89, 245 nM respectively; Kiapp: 0.68, 55.7 nM respectively). Ac-DNLD-CHO can be used for research of caspase-mediated apoptosis diseases, such as neurodegenerative disorders and viral infection diseases[1]. | [Biological Activity]
Cell permeable: no''Primary Target
caspase-3caspase-7''Product does not compete with ATP.''Reversible: yes''Target IC50: 3.2 nM and 22.6 nMagainst caspases-3 and -7respectively | [References]
[1] Yoshimori A, et al. Structural and functional definition of the specificity of a novel caspase-3 inhibitor, Ac-DNLD-CHO. BMC Pharmacol. 2007 Jun 27;7:8. DOI:10.1186/1471-2210-7-8 |
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| Company Name: |
Merck Millipore
|
| Tel: |
1-400-889-1988 400-889-1988 |
| Website: |
http://www.merckmillipore.com |
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Website: |
www.enzo.com |
|