| Identification | Back Directory | [Name]
3-[1-hydroxy-2-[(4-phenylphenyl)methylamino]ethyl]phenol | [CAS]
775294-71-8 | [Synonyms]
3-[1-hydroxy-2-[(4-phenylphenyl)methylamino]ethyl]phenol
Benzenemethanol, α-[[([1,1'-biphenyl]-4-ylmethyl)amino]methyl]-3-hydroxy- | [Molecular Formula]
C21H21NO2 | [MDL Number]
MFCD05881892 | [MOL File]
775294-71-8.mol | [Molecular Weight]
319.4 |
| Chemical Properties | Back Directory | [Boiling point ]
551.8±50.0 °C(Predicted) | [density ]
1.181±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.75±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
AC-73 is an inhibitor of HCC mobility and invasion. It acts by disrupting CD147 dimerization and thereby mainly suppressing the CD147/ERK1/2/STAT3/MMP-2 pathways, which are crucial for cancer progression. | [Uses]
AC-73 is a first specific, orally active inhibitor of cluster of differentiation 147 (CD147), which specifically disrupts CD147 dimerization, thereby mainly suppressing the CD147/ERK1/2/STAT3/MMP-2 pathways. AC-73 inhibits the motility and invasion of hepatocellular carcinoma cells[1]. AC-73 is also an anti-proliferative agent and an inducer of autophagy in leukemic cells[2]. | [in vivo]
AC-73 (25-50 mg/kg; for 4 weeks; Male BALB/c nu/nu mice) treatment significantly decreases the incidence of metastatic foci in nude mice. AC-73 inhibits the phosphorylation of ERK1/2 and STAT3 in a dose-dependent manner. MMP-2 is also reduced by AC-73. AC-73 could not inhibit tumor cell proliferation in vivo[1]. | Animal Model: | Male BALB/c nu/nu mice (4-6 weeks) with SMMC-7721 cells[1] | | Dosage: | 25 mg/kg, 50 mg/kg | | Administration: | Injected; daily; for 3 weeks | | Result: | Significantly decreased the incidence of metastatic foci in nude mice. Inhibited the phosphorylation of ERK1/2 and STAT3 in a dose-dependent manner. MMP-2 was also reduced.
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| [References]
[1] Fu ZG, et al. A novel small-molecule compound targeting CD147 inhibits the motility and invasion of hepatocellular carcinoma cells. Oncotarget. 2016 Feb 23;7(8):9429-47. DOI:10.18632/oncotarget.6990
[2] Spinello I, et al. The small-molecule compound AC-73 targeting CD147 inhibits leukemic cell proliferation, induces autophagy and increases the chemotherapeutic sensitivity of acute myeloid leukemia cells. Haematologica. 2019 May;104(5):973-985. DOI:10.3324/haematol.2018.199661 |
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