| Identification | Back Directory | [Name]
beta-endorphin (6-31) | [CAS]
77761-27-4 | [Synonyms]
beta-endorphin (6-31)
6-31-β-Endorphin (human)
b-Lipotropin (64-89) (huMan)
H-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu-OH | [Molecular Formula]
C131H218N34O40 | [MOL File]
77761-27-4.mol | [Molecular Weight]
2909.36 |
| Hazard Information | Back Directory | [Uses]
β-Endorphin, an endogenous opioid neuropeptide, is an opioid receptor agonist. β-Endorphin binds preferentially to μ-opioid receptors and is produced in certain neurons of the central and peripheral nervous system and is one of three endorphins produced in humans. β-Endorphin can be used to reduce stress and maintain homeostasis in the body and is involved in neurological pain perception regulation[1]. | [in vivo]
β-Endorphin (0.03 to 1.00?μg/kg, i.p., once) impairs retention of a one-trial inhibitory avoidance task in a dose-dependent manner in male Swiss mice immediately post-training. Also, it works in the process of memory consolidation[1].
| Animal Model: | Adult male Swiss mice (22-25 g)[1] | | Dosage: | 0.03, 0.10, 0.30 or 1.00 μg/kg | | Administration: | i.p., once | | Result: | Significantly impaired retention at the doses of 0.03 and 0.10?μg/kg while not significantly affect retention as compared with the control group at the two higher doses of 0.30 and 1.00?μg/kg , but tended to increase retention as compared with the dose of 0.10?μg/kg.
Increased latencies to step-through at the two higher doses of 0.30 and 1.00?μg/kg but no effect at lower doses. |
| [References]
[1] Introini IB, et al. The impairment of retention induced by beta-endorphin in mice may be mediated by a reduction of central cholinergic activity. Behav Neural Biol. 1984 Jul;41(2):152-63. DOI:10.1016/s0163-1047(84)90527-2 |
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