| Identification | Back Directory | [Name]
3-[3-(4-methoxyphenyl)-5-methyl-7-oxofuro[3,2-g]chromen-6-yl]propanoic acid | [CAS]
777857-56-4 | [Synonyms]
Scaff108
Scaff10 8
Scaff10-8
Scaff-10-8
Scaff 10 8
3-[3-(4-methoxyphenyl)-5-methyl-7-oxofuro[3,2-g]chromen-6-yl]propanoic acid | [Molecular Formula]
C22H18O6 | [MOL File]
777857-56-4.mol | [Molecular Weight]
378.37 |
| Chemical Properties | Back Directory | [Melting point ]
233-234 °C(Solv: isopropanol (67-63-0)) | [Boiling point ]
626.0±55.0 °C(Predicted) | [density ]
1.313±0.06 g/cm3(Predicted) | [pka]
4.36±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Scaff10-8 is an AKAP-Lbc-RhoA interaction inhibitor. It acts by promoting the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells. | [Uses]
Scaff10-8, bound to RhoA, inhibits the AKAP-Lbc-mediated RhoA activation[1]. | [References]
[1] Schrade K, et al. An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells. PLoS One. 2018;13(1):e0191423. Published 2018 Jan 26. DOI:10.1371/journal.pone.0191423 |
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| Company Name: |
PHARMEKS Ltd.
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| Tel: |
+7 (495) 702-9648 |
| Website: |
www.pharmeks.com |
| Company Name: |
OTAVA chemicals
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| Tel: |
416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
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