| Identification | Back Directory | [Name]
N1-ACETYLSPERMINE TRIHYDROCHLORIDE | [CAS]
77928-70-2 | [Synonyms]
1-ACETYLSPERMINE TRIHYDROCHLORIDE
N1-Acetylspermine (hydrochloride)
N1-ACETYLSPERMINE TRIHYDROCHLORIDE
N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)acetamide trihydrochloride | [Molecular Formula]
C12H31Cl3N4O | [MDL Number]
MFCD00083219 | [MOL File]
77928-70-2.mol | [Molecular Weight]
353.76 |
| Chemical Properties | Back Directory | [Melting point ]
>256°C (dec.) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [BRN ]
7052482 | [InChI]
1S/C12H28N4O.3ClH/c1-12(17)16-11-5-10-15-8-3-2-7-14-9-4-6-13;;;/h14-15H,2-11,13H2,1H3,(H,16,17);3*1H | [InChIKey]
QQSPUTBJDXPUCR-UHFFFAOYSA-N | [SMILES]
Cl[H].Cl[H].Cl[H].CC(=O)NCCCNCCCCNCCCN |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26-36 | [WGK Germany ]
3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
N1-Acetylspermine is a monoacetylated derivative of spermine , an endogenous polyamine synthesized from spermidine , that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. N1-Acetylspermine has been used to study the uptake of the anticancer polyamine analog bleomycin-A5 by the human carnitine transporter SLC22A16. | [Uses]
N1-Acetylspermine trihydrochloride has been used in a study to determine that the human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. | [References]
[1] MUSTAPHA AOUIDA Dindial R Richard Poulin. The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5.[J]. The Journal of Biological Chemistry, 2010: 6275-6284. DOI: 10.1074/jbc.m109.046151 |
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