| Identification | Back Directory | [Name]
CAY10397 | [CAS]
78028-01-0 | [Synonyms]
CK47A
CAY10397
Ph CK 47A
CAY-10397,CAY10397
DPHOCQNZARWEHS-UHFFFAOYSA-N
5-[[4-(ETHOXYCARBONYL)PHENYL]AZO]-2-HYDROXY-BENZENEACETIC ACID
5-[2-[4-(Ethoxycarbonyl)phenyl]diazenyl]-2-hydroxybenzeneacetic acid
5-[[4-(Ethoxycarbonyl)phenyl]azo]-2-hydroxybenzeneacetic acid, CK47A | [Molecular Formula]
C17H16N2O5 | [MDL Number]
MFCD03412024 | [MOL File]
78028-01-0.mol | [Molecular Weight]
328.32 |
| Chemical Properties | Back Directory | [Boiling point ]
578.0±50.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
0.1 M Na2CO3: 200 μg/ml; DMF: 35 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml | [form ]
solid | [pka]
4.05±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Prostaglandins are rapidly inactivated in vivo by the action of 15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH). This enzyme oxidizes the 15-hydroxyl group and hydrogenates the 13,14-double bond, producing 13,14-dihydro-15 keto metabolites with greatly reduced biological activity. CAY10397 is a selective inhibitor of 15-hydroxy PGDH with an IC50 of approximately 10 μM. CAY10397 acts to prolong the lifetime and activity of endogenously produced prostaglandins both in cell culture and in vivo.[Cayman Chemical] | [Definition]
ChEBI:CAY10397 is a member of the class of azobenzenes that is azobenzene in which one of the phenyl groups is substituted at position 4 by an ethoxycarbonyl group, while the other is substituted by a carboxymethyl group at position 3 and a hydroxy group at position 4. It is a potent and selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-hydroxy-PGDH). It has a role as an EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor. It is a dicarboxylic acid monoester, an ethyl ester, a member of azobenzenes and a member of phenols. | [Biological Activity]
Potent and selective inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-hydroxy-PGDH). Acts to prolong the lifetime and activity of endogenously produced prostaglandins both in vitro and in vivo. |
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