| Identification | Back Directory | [Name]
2-(bromomethyl)-6-(trifluoromethyl)pyridine | [CAS]
781637-62-5 | [Synonyms]
2-(bromomethyl)-6-(trifluoromethyl)pyridine | [Molecular Formula]
C7H5BrF3N | [MDL Number]
MFCD15526798 | [MOL File]
781637-62-5.mol | [Molecular Weight]
240.02 |
| Chemical Properties | Back Directory | [Boiling point ]
190.1±35.0 °C(Predicted) | [density ]
1.647±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [pka]
-1.24±0.24(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2-(bromomethyl)-6-(trifluoromethyl)pyridine using 2-methyl-6-(trifluoromethyl)pyridine as starting material: 2-methyl-6-(trifluoromethyl)pyridine (100 mg, 0.620 mmol) was dissolved in carbon tetrachloride (CCl4, 3 mL), and N-bromosuccinimide (NBS, 110 mg, 0.620 mmol) and 1,1'-azobis(cyclohexanenitrile) (VAZO, 8 mg, 0.031 mmol). The reaction mixture was heated and stirred at 90 °C for 15 hours. After completion of the reaction, the reaction solution was filtered and the filtrate was concentrated under reduced pressure. The resulting residue was purified by medium pressure liquid chromatography (MPLC, hexane/ethyl acetate = 5:1) to afford 2-(bromomethyl)-6-(trifluoromethyl)pyridine as a white solid (42.5 mg, 28.4% yield).1H NMR (300 MHz, CDCl3) δ 4.60 (2H, s), 7.61 (1H, d), 7.68 (1H, d) , 7.90 (1H, t). | [References]
[1] Patent: WO2013/129879, 2013, A1. Location in patent: Page/Page column 50; 51
[2] Patent: US2015/166558, 2015, A1. Location in patent: Paragraph 0300; 0301; 0302 |
|
|