| Identification | Back Directory | [Name]
2,4-Imidazolidinedione-2-13C-1,3-15N2, 5,5-diphenyl- (9CI) | [CAS]
78213-26-0 | [Synonyms]
5,5-Diphenylhydantoin (2-13C, 99%
1,3-1?N?, 98%) 100 μg/mL in methanol
1,3-15N2, 98%) 100 UG/ML IN METHANOL
2,4-Imidazolidinedione-2-13C-1,3-15N2, 5,5-diphenyl- (9CI) | [Molecular Formula]
C15H12N2O2 | [MDL Number]
MFCD00143403 |
| Hazard Information | Back Directory | [Uses]
Phenytoin-15N2,13C is the 13C and 15N labeled Phenytoin[1]. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[2][3]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5(7): p. 553-64. DOI:10.1038/nrn1430
[3] Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81. DOI:10.1016/B978-0-444-52899-5.00021-6
[4] Balaji, S., Medical therapy for sudden death. Pediatr Clin North Am, 2004. 51(5): p. 1379-87. DOI:10.1016/j.pcl.2004.04.002
[5] Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 2714(1):13. DOI:10.1186/s12943-014-0277-x |
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