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78213-63-5

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78213-63-5 Structure

78213-63-5 Structure
IdentificationBack Directory
[Name]

PIRIBEDIL HYDROCHLORIDE
[CAS]

78213-63-5
[Synonyms]

PiribedilHCl
PIRIBEDIL HYDROCHLORIDE
Piribedil dihydrochloride
2-(4-piperonyl-1-piperazinyl)pyrimidinehydrochloride
2-(4-piperonyl-1-piperazinyl)-pyrimidinhydrochloride
2-(4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)-pyrimidinmonohydrochlor
2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL]PYRIMIDINE HYDROCHLORIDE
2-[4-(1,3-BENZODIOXOL-5-YLMETHYL)-1-PIPERAZINYL]PYRIMIDINIE HYDROCHLORIDE
2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidinedihydrochloride
[Molecular Formula]

C16H19ClN4O2
[MDL Number]

MFCD01689349
[MOL File]

78213-63-5.mol
[Molecular Weight]

334.8
Chemical PropertiesBack Directory
[storage temp. ]

Store at RT
Hazard InformationBack Directory
[Uses]

Piribedil dihydrochloride is a useful dopaminergic for biological research purposes.
[Biological Activity]

A direct dopamine agonist, in clinical use for treatment of dopaminergic system dysfunction. Recent work suggests that it is selective for the D 3 subtype, for which it has 20 times higher affinity than for D 2 , and possesses no significant affinity for D 1 ? receptors.
[in vivo]

Piribedil hydrochloride (intraperitoneal injection, 5, 15, 40 mg/kg ) alleviates the L-DOPA-induced dyskinesias in rats model of Parkinson’s disease[2].
Piribedil hydrochloride (oral gavage, 4-5 mg/kg, daily for 2 weeks) increases locomotor activity and reversal of motor deficits in adult common marmosets[3].
Piribedil hydrochloride (oral gavage, 150 mg/kg, daily for 21 days) inhibits MLL-r tumor growth and decreases the expression of MLL1 target genes in MV4;11 tumor xenografts[4].

Animal Model:Rat model of Parkinson’s disease[2]
Dosage:5, 15, 40 mg/kg
Administration:Intraperitoneal injection, administered 5 min before administration of L-DOPA.
Result:Reduced turning behaviour and AD (axial dystonia), OD (orolingual dyskinesia) and FD (forelimb dyskinesia) at 5 and 40 mg/kg.
Increased LD (locomotive dyskinesias) at the 40 mg/kg.
Animal Model:Adult common marmosets[3]
Dosage:4-5 mg/kg
Administration:Oral gavage, daily for 2 weeks
Result:Increased vigilance and alertness and reversed the downregulation of preprotachykinin mRNA induced by MPTP in rostral and caudal striatum.
[IC 50]

D2 Receptor; D3 Receptor
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