| Identification | Back Directory | [Name]
10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-, hydrochloride (1:1) | [CAS]
783334-36-1 | [Synonyms]
10H-Thieno[2,3-b][1,5]benzodiazepine, 2-methyl-4-(4-methyl-1-piperazinyl)-, hydrochloride (1:1) | [Molecular Formula]
C17H21ClN4S | [MOL File]
783334-36-1.mol | [Molecular Weight]
348.89 |
| Hazard Information | Back Directory | [Uses]
Olanzapine hydrochloride is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine hydrochloride is an atypical antipsychotic[1][2]. | [References]
[1] APPROVED AGREED-UPON LABELING.
[2] Olanzapine for Injection, powder, for solution for intramuscular use.
[3] Vucicevic L, et al. Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine. Autophagy. 2014;10(12):2362-78. DOI:10.4161/15548627.2014.984270
[4] Karpel-Massler G, et al. Olanzapine inhibits proliferation, migration and anchorage-independent growth in human glioblastoma cell lines and enhances temozolomide's antiproliferative effect. J Neurooncol. 2015 Mar;122(1):21-33. DOI:10.1007/s11060-014-1688-7
[5] Coccurello R, et al. Chronic administration of olanzapine induces metabolic and food intake alterations: a mousemodel of the atypical antipsychotic-associated adverse effects. Psychopharmacology (Berl). 2006 Jul;186(4):561-71. DOI:10.1007/s00213-006-0368-5 |
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