| Identification | Back Directory | [Name]
MY-5445 | [CAS]
78351-75-4 | [Synonyms]
MY-5445
MY 5445;MY5445
1-(3-CHLOROANILINO)-4-PHENYLPHTHALAZINE
1-(3-CHLOROPHENYLAMINO)-4-PHENYLPHTHALAZINE
1-(3-Chloroanilino)-4-phenylphthalazine >
N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine
N-(3-chlorophenyl)-4-phenylphthalazin-1-amine | [Molecular Formula]
C20H14ClN3 | [MDL Number]
MFCD00209838 | [MOL File]
78351-75-4.mol | [Molecular Weight]
331.8 |
| Chemical Properties | Back Directory | [Boiling point ]
539.7±50.0 °C(Predicted) | [density ]
1.310±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml | [form ]
Yellow solid. | [pka]
4.91±0.30(Predicted) | [color ]
White to Light yellow |
| Hazard Information | Back Directory | [Description]
MY-5445 is a selective inhibitor of the cyclic GMP (cGMP) phosphodiesterase, PDE5, with a Ki value of 1.3 μM. It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 μM, respectively. MY-5445 has been shown to relax intact strips of rat aorta with an EC50 value of 4 μM. | [Uses]
Selective inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50=0.6μM). | [Definition]
ChEBI: N-(3-chlorophenyl)-4-phenyl-1-phthalazinamine is a ring assembly and a member of pyridazines. | [Biological Activity]
Specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5 (IC 50 = 0.5 μ M). | [in vivo]
MY-5445 (0.5-3 mg/kg; i.p.; twice a day; for 15 days) produces a significant relief of mechanical hypersensitivity[3].
| Animal Model: | C57BL/6J male mice[3] | | Dosage: | 0.5 mg/kg, 3 mg/kg | | Administration: | Intraperitoneal injection, twice a day, for 15 days | | Result: | Alleviated the cuff-induced allodynia. |
| [IC 50]
PDE5: 1.3 μM (Ki); PDE5: 6.7 μM (IC50); PDE4: 37 μM (IC50) | [References]
[1] JOHN E. SOUNESS. Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine[J]. British Journal of Pharmacology, 1989, 98 3: 725-734. DOI: 10.1111/j.1476-5381.1989.tb14599.x
[2] T YAMAMOTO. Complex effects of inhibitors on cyclic GMP-stimulated cyclic nucleotide phosphodiesterase.[J]. The Journal of Biological Chemistry, 1983, 258 23: 14173-14177.
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|