| Identification | Back Directory | [Name]
Razobazam | [CAS]
78466-98-5 | [Synonyms]
HOE 175
Razobazam
Razobazamum
4,8-Dihydro-3,8-dimethyl-4-phenylpyrazolo[3,4-b][1,4]diazepine-5,7(1H,6H)-dione
Pyrazolo[3,4-b][1,4]diazepine-5,7(1H,4H)-dione, 6,8-dihydro-3,8-dimethyl-4-phenyl- | [Molecular Formula]
C14H14N4O2 | [MDL Number]
MFCD00867784 | [MOL File]
78466-98-5.mol | [Molecular Weight]
270.29 |
| Hazard Information | Back Directory | [Uses]
Razobazam (Hoe 175) is a benzodiazepine derivative with cognitive activity. Razobazam has been shown to improve learning performance in socially deprived rats. Razobazam increased avoidance scores by 18% after training. Razobazam caused significant changes in the optical density of certain areas of the rat brain, including a 22% decrease in the lateral habenula and a 25% increase in the ventral tegmental area. Razobazam also caused a 13% increase in optical density in the prefrontal cortex of rats[1]. | [References]
[1] Functional activity in the brain of socially deprivated rats produced by an active avoidance test after razobazam (Hoe 175) treatment: a 2-deoxyglucose study DOI:10.1016/s0163-1047(86)90401-2 |
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