| Identification | Back Directory | [Name]
excisanin A | [CAS]
78536-37-5 | [Synonyms]
1α,7α,12α,14β-Tetrahydroxykaura-16-ene-15-one
(14R)-1α,7α,12α,14-Tetrahydroxykaur-16-en-15-one
Kaur-16-en-15-one, 1,7,12,14-tetrahydroxy-, (1α,7α,12α,14R)-
1alpha,7alpha,12alpha,14beta-Tetrahydroxy-ent-kaur-16-en-15-one | [Molecular Formula]
C20H30O5 | [MDL Number]
MFCD32644906 | [MOL File]
78536-37-5.mol | [Molecular Weight]
350.452 |
| Hazard Information | Back Directory | [Description]
Excisanin A is a diterpenoid compound purified from Isodon macrocalyxin D that has anti-cancer properties with little toxicity. | [Uses]
Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer[1]. | [References]
[1] Qin J, et al. A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin β1/FAK/PI3K/AKT/β-catenin signaling. Life Sci. 2013 Nov 4;93(18-19):655-63. DOI:10.1016/j.lfs.2013.09.002 |
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