| Identification | Back Directory | [Name]
N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE | [CAS]
78538-74-6 | [Synonyms]
LSU-65
FG 7142
ZK 39106
Zk-31906
β-CCA methylamide
N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE
B-carboline-3-carboxylic acid N-*methylamide
4-b)indole-3-carboxamide,n-methyl-9h-pyrido(
n-methyl-9h-pyrido(3,4-b)indole-3-carboxamide
β-Carboline-3-carboxylic acid N-methylamide
N-METHYL-B-CARBOLINE-3-CARBOXAMIDE (FG-7 142)
beta-carboline-3-carboxylic acid N-methylamide
9H-beta-Carboline-3-carboxylic acid methylamide
9H-Pyrido(3,4-B)indole-3-carboxamide, N-methyl-
β-CCA methylamide, FG-7142, N-Methyl-β-carboline-3-carboxamide | [Molecular Formula]
C13H11N3O | [MDL Number]
MFCD00055075 | [MOL File]
78538-74-6.mol | [Molecular Weight]
225.25 |
| Questions And Answer | Back Directory | [Description]
FG 7142 (ZK 39106; LSU-65) is a nonselective benzodiazepine inverse agonist with high affinity (Ki= 91 nM) for the α1 subunit-containing GABAA receptor. FG 7142 also modulates GABA-induced chloride flux (EC50=137 nM) at GABAA receptors expressing the α1 subunit. FG 7142 increases tyrosine hydroxylation and leads to upregulation of β-adrenergic receptors in mouse cerebral cortex. |
| Chemical Properties | Back Directory | [Melting point ]
269-270° | [Boiling point ]
576.3±30.0 °C(Predicted) | [density ]
1.328±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
ethanol: 1 mg/mL
| [form ]
A crystalline solid | [pka]
13.44±0.46(Predicted) | [color ]
light tan
| [InChI]
1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17) | [InChIKey]
QMCOPDWHWYSJSA-UHFFFAOYSA-N | [SMILES]
CNC(=O)c1cc2c(cn1)[nH]c3ccccc23 |
| Hazard Information | Back Directory | [Uses]
FG 7142 is a benzodiazepine inverse agonist anxiogenic compound. | [Definition]
ChEBI: N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide is a member of beta-carbolines. | [Biological Activity]
Inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β -adrenoceptors in mouse cerebral cortex. | [Biochem/physiol Actions]
Benzodiazepine inverse receptor agonist; potent anxiogenic agent. | [storage]
Store at RT |
|
| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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