| Identification | Back Directory | [Name]
GW 876008X | [CAS]
786701-13-1 | [Synonyms]
GW876008
GW 876008X
EMicerfont
786701-13-1
1-[1-[1-(4-methoxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo[2,3-b]pyridin-4-yl]pyrazol-3-yl]imidazolidin-2-one
2-Imidazolidinone, 1-[1-[2,3-dihydro-1-(4-methoxy-2-methylphenyl)-6-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-3-yl]- | [Molecular Formula]
C22H24N6O2 | [MDL Number]
MFCD18782717 | [MOL File]
786701-13-1.mol | [Molecular Weight]
404.46 |
| Chemical Properties | Back Directory | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.73±0.20(Predicted) | [color ]
Light yellow to brown |
| Hazard Information | Back Directory | [Uses]
Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM. | [Definition]
ChEBI: Emicerfont is an aromatic amine and a tertiary amino compound. | [in vivo]
At concentration of 10 mg/kg, Emicerfont reduces i.c.v. CRF-induced gerbil forepaw treading and marmoset defensive postures. Emicerfont also reduces rat pup ultrasonic vocalization at concentration of 30 mg/kg[1]. | [storage]
Store at -20°C | [References]
[1] Zorrilla EP, et al. Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. Drug Alcohol Depend. 2013 Mar 1;128(3):175-86. DOI:10.1016/j.drugalcdep.2012.12.017 |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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