| Hazard Information | Back Directory | [Description]
LY 88329 is a phenylpiperidine narcotic antagonist. | [Uses]
LY 88329 is a potent narcotic antagonist[1]. | [in vivo]
LY 88329 (0.16, 0.32, 0.64, 1.25, 2.5, 5 mg/kg; intramuscular injection; twice a week) shows narcotic antagonist activity in pigeons[1]. | Animal Model: | Male White Carneaux pigeons[1] | | Dosage: | 0.16, 0.32, 0.64, 1.25, 2.5, 5 mg/kg (20 mg/kg of morphine) | | Administration: | Intramuscular injection; twice a week | | Result: | Produced some antagonism of the effects of 20 mg/kg of morphine, bringing suppressed rates of responding back towards the 100% of control level and reversing the morphine-induced decrease in quarter-life value in birds. |
| [References]
[1] Leander JD. Behavioral effects of phenylpiperidine narcotic antagonists. Pharmacol Biochem Behav. 1981 Jul;15(1):65-70. DOI:10.1016/0091-3057(81)90340-3 |
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