| Identification | Back Directory | [Name]
Cyclopenta[c][1]benzopyran-8-ol, 2,2-difluoro-1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aS,4R,9bR)- | [CAS]
787621-78-7 | [Synonyms]
Estrogen receptor modulator 6
Cyclopenta[c][1]benzopyran-8-ol, 2,2-difluoro-1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aS,4R,9bR)- | [Molecular Formula]
C18H16F2O3 | [MOL File]
787621-78-7.mol | [Molecular Weight]
318.31 |
| Hazard Information | Back Directory | [Uses]
Estrogen receptor modulator 6 (compound 3a) is a selective estrogen receptor (ER) β agonist (Ki=0.44 nM). Estrogen receptor modulator 6 displays 19-fold selectivity for ERβ over ERα(Ki=8.4 nM)[1]. | [IC 50]
ERβ: 0.44 nM (Ki); ERα: 8.4 nM (Ki) | [References]
[1] Richardson TI, et al. Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 5: Combined A- and C-ring structure-activity relationship studies. Bioorg Med Chem Lett. 2007;17(20):5563-5566. DOI:10.1016/j.bmcl.2007.08.009 |
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