| Identification | Back Directory | [Name]
Carbamic acid, N,N-dimethyl-, 5-[(1R)-2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-phenylene ester | [CAS]
788821-30-7 | [Synonyms]
Carbamic acid, N,N-dimethyl-, 5-[(1R)-2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-phenylene ester | [Molecular Formula]
C18H29N3O5 | [MOL File]
788821-30-7.mol | [Molecular Weight]
367.44 |
| Hazard Information | Back Directory | [Uses]
(R)-Bambuterol is a β2-receptor agonist with anti-asthmatic and colitis-improving activity. (R)-Bambuterol is indicated for the treatment of asthma and chronic obstructive pulmonary disease and has the advantage of a once-daily dosing and a favorable side effect profile. (R)-Bambuterol significantly reduced disease severity in a mouse model of colitis, more effectively than (RS)-Bambuterol or (S)-Bambuterol. (R)-Bambuterol can significantly reduce the levels of inflammatory cytokines and reduce the infiltration of macrophages in mice with colitis. (R)-Bambuterol also increases β2-adrenoceptor levels and reduces the expression of IL-6, IL-17 and other related proteins in colon tissue in a dose-dependent manner[1]. | [Definition]
ChEBI: (R)-bambuterol is the (R)-enantiomer of bambuterol. It is an enantiomer of a (S)-bambuterol. | [References]
[1] (RS)-bambuterol and its enantiomers: Potential improvement of (R)-bambuterol in mice with colitis DOI:10.1016/j.intimp.2021.108501 |
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