| Identification | Back Directory | [Name]
Quinacrine acetate | [CAS]
78901-94-7 | [Synonyms]
Quinacrine acetate
N4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine monoacetate
1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-, monoacetate | [Molecular Formula]
C25H34ClN3O3 | [MOL File]
78901-94-7.mol | [Molecular Weight]
460.009 |
| Hazard Information | Back Directory | [Description]
Quinacrine acetate is a histamine N-methyltransferase inhibitor. | [Uses]
Quinacrine (Acriquine) acetate is a small molecule modulator of the cGAS-STING-TBK1 signaling pathway, possessing immune stimulatory activity. Quinacrine acetate has been explored for its potential therapeutic applications in enhancing anti-tumor immunity. Quinacrine acetate can improve the effectiveness of cancer immunotherapies by addressing the poor immunogenicity of various tumors. Quinacrine acetate also presents a promising strategy for overcoming the limitations associated with immune checkpoint inhibitors in cancer treatment. | [References]
[1] Small molecules targeting the innate immune cGAS?STING?TBK1 signaling pathway DOI:10.1016/j.apsb.2020.03.001 |
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