| Identification | Back Directory | [Name]
6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride | [CAS]
789488-77-3 | [Synonyms]
ENMD-1068
ENMD-1068
(ENMD1068)
ENMD-1068 hydrochloride
6-amino-1-[4-(3-methylbutanoyl)piperazin-1-yl]hexan-1-one
6-Amino-1-[4-(3-methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone hydrochloride | [Molecular Formula]
C15H29N3O2 | [MDL Number]
MFCD16817498 | [MOL File]
789488-77-3.mol | [Molecular Weight]
283.41 |
| Chemical Properties | Back Directory | [Boiling point ]
478.7±40.0 °C(Predicted) | [density ]
1.047±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble25mg/mL, clear | [form ]
powder | [pka]
10.57±0.10(Predicted) | [color ]
white to beige | [Water Solubility ]
Water: 25 mg/mL，clear | [InChI]
1S/C15H29N3O2/c1-13(2)12-15(20)18-10-8-17(9-11-18)14(19)6-4-3-5-7-16/h13H,3-12,16H2,1-2H3 | [InChIKey]
VRZYMMVEALDDBH-UHFFFAOYSA-N | [SMILES]
N1(CCN(CC1)C(=O)CCCCCN)C(=O)CC(C)C |
| Hazard Information | Back Directory | [Uses]
ENMD-1068 hydrochloride has been used as a protease-activated receptor 2 (PAR2) antagonist to determine the pathway responsible for paw edema induced by Crotalus durissus terrificus venom serine protease (Cdtsp 2). | [Biochem/physiol Actions]
ENMD-1068 is an antagonist of protease-activated receptor 2 (PAR2). The compound blocks TNFα production in synovial explants from patients with arthritis, and inhibits mast cell tryptase-induced recruitment of eosinophils into the pleural cavity of mice. |
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