| Identification | Back Directory | [Name]
Guan-fu base G | [CAS]
78969-72-9 | [Synonyms]
Guan fu base G
Guan-fu base G
(2α,11α,13R)-Hetisan-2,11,13,14-tetrol 2,11,13-triacetate
Hetisan-2,11,13,14-tetrol, 2,11,13-triacetate, (2α,11α,13R)- | [Molecular Formula]
C26H33NO7 | [MOL File]
78969-72-9.mol | [Molecular Weight]
471.54 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the tuberous root of Aconitum carmichaelii (Kanbaifu), a plant of the Ranunculaceae family. | [Uses]
Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits HERG channel current with an IC50 of 17.9 μM[1][2]. | [in vivo]
Guanfu base G (5 mg/kg; intravenous injection; for 5-1200 minutes; rats) treatment in rats after 15 min could be detected the presence of Guanfu base A, about 10% of Guanfu base G in vivo could metabolize to Guanfu base A, which may be related to the metabolic enzymes in the body and its nature-related compounds, however, the substance in the body to eliminate more quickly, could be detected only around 240 min. The pharmacokinetic behavior of Guanfu base G is better in rats, the T1/2 is 4.16 hours. These results indicate that Guanfu base G has a relatively suitable elimination half-life[1]. | Animal Model: | Rats[1] | | Dosage: | 5 mg/kg | | Administration: | Intravenous injection; for 5, 15, 30, 45, 60, 120, 240, 360, 480, 600, 720, 960 and 1200 minutes (Pharmacokinetic study) | | Result: | The pharmacokinetic behavior was better in rats, the T1/2 was 4.16 hours.
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| [References]
[1] Zhang L, et al. Simultaneous determination of Guanfu base G and its active metabolites by UPLC-MS/MS in rat plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:1-6. DOI:10.1016/j.jchromb.2014.02.024
[2] Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83. DOI:10.1097/FJC.0b013e318236e380 |
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