ChemicalBook--->CAS DataBase List--->791828-58-5

791828-58-5

Request For Quotation
791828-58-5 Structure

791828-58-5 Structure
IdentificationBack Directory
[Name]

aderbasib
[CAS]

791828-58-5
[Synonyms]

Incb7839
aderbasib
INCB 007839
Unii-V9yl6nej3g
(6S,7S)-Methyl 7-(hydroxycarbamoyl)-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-5-
(6S,7S)-Methyl 7-(hydroxycarbamoyl)-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-5-car
Methyl (6S,7S)-7-(hydroxycarbamoyl)-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylate
(6S,7S)-Methyl 7-(hydroxycarbaMoyl)-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylate
5-Azaspiro2.5octane-5-carboxylicacid, 7-(hydroxyaMino)carbonyl-6-(4-phenyl-1-piperazinyl)carbonyl-, Methylester, (6S,7S)-
(6S,7S)-7-[(Hydroxyamino)carbonyl]-6-[(4-phenyl-1-piperazinyl)carbonyl]-5-azaspiro[2.5]octane-5-carboxylic acid methyl ester
[Molecular Formula]

C21H28N4O5
[MDL Number]

MFCD13195569
[MOL File]

791828-58-5.mol
[Molecular Weight]

416.47
Chemical PropertiesBack Directory
[density ]

1.38
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 100 mg/mL (240.11 mM; Need ultrasonic)
[form ]

Solid
[pka]

9.33±0.23(Predicted)
[color ]

White to light yellow
Hazard InformationBack Directory
[Uses]

Aderbasib is a azaspiro[2.5]octanehydroxamide derivative as inhibitor of metalloproteases for the treatment of disorders such as cancer, arthritis, cardiovascular or skin disorders.
[in vivo]

Aderbasib (intraperitoneal injection; 50 mg/kg; 5 days per week beginning four weeks; 2 weeks) blocks glioma growth of SU-pcGBM2 NSG mice xenografts[1].INCB7839 can be formulated in 2% DMSO, 2% Tween 80, 48% PEG300, 48% water as a injection solution. This is for literature reference only[1].

Animal Model:NSG mice[1]
Dosage:50 mg/kg
Administration:Intraperitoneal injection; 50 mg/kg; 5 days per week beginning four weeks; 2 weeks
Result:Robustly inhibited growth of pediatric glioblastoma orthotopic xenografts.
[IC 50]

ADAM10; ADAM17
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

aderbasib(791828-58-5)1HNMR
791828-58-5 suppliers list
Company Name: Chemsky (shanghai) International Co.,Ltd  
Telephone: 021-50135380
Website: www.shchemsky.com
Company Name: Shanghai Fuhe Chemistry Technology Co., Ltd.  
Telephone: 0086-21-67651709
Website: www.chemicalbook.com/ShowSupplierProductsList15402/0_EN.htm
Company Name: Shanghai Lollane Biological Technology Co.,Ltd.  
Telephone: 021-52996696，15000506266 15000506266
Website: http://www.bioll.com
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Telephone: 15026964105
Website: www.shyuanye.com
Company Name: Amadis Chemical Company Limited  
Telephone: 571-89925085
Website: http://www.amadischem.com
Company Name: Chongqing Chemieliva Pharmaceutical Co., Ltd.  
Telephone: 18696571988
Website: http://www.chemieliva.com
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.  
Telephone: +86-0551-65418684 +86-18949823763
Website: www.tnjchem.com
Company Name: HUNAN CHEMFISH SCIENTIFIC CO.,LTD  
Telephone: 0731-85567275 19073112098
Website: www.chemfish.com/
Company Name: CONIER CHEM AND PHARMA LIMITED  
Telephone:
Website: http://www.conier.com/
Company Name: Shaanxi Dideu Medichem Co. Ltd  
Telephone: 029-81154043 17391733319
Website: http://www.dideu.cn
Company Name: Chunchuang (Wuhan) Technology Co., Ltd  
Telephone: 15727060112
Website: www.chemicalbook.com/showsupplierproductslist1427518/0_en.htm
Company Name: Energy Chemical  
Telephone: 021-58432009 400-005-6266
Website: http://www.energy-chemical.com
Company Name: Bide Pharmatech Ltd.  
Telephone: 400-1647117 13681763483
Website: https://www.bidepharm.com/
Company Name: TargetMol Chemicals Inc.  
Telephone: 4008200310 15002144251
Website: https://www.targetmol.cn/
Company Name: Shanghai Tachizaki Biomedical Research Center  
Telephone: 18014399201
Website: http://www.chemlab-tachizaki.com/
Company Name: Nantong QuanYi Biotechnology Co., Ltd  
Telephone: 0513-66337626 18051384581
Website: https://www.chemhifuture.com/
Company Name: PharmaBlock Sciences (Nanjing), Inc.  
Telephone: 4000255188
Website: www.pharmablock.com/
Company Name: Accela ChemBio Co.,Ltd.  
Telephone: 021-50795510 4000665055
Website: https://www.shao-yuan.com
Tags:791828-58-5 Related Product Information