| Identification | Back Directory | [Name]
1,3-Dihydro-1,4-diphenyl-2H-imidazole-2-thione | [CAS]
79220-94-3 | [Synonyms]
KRM-III
KRM-III >=98% (HPLC)
1,3-Dihydro-1,4-diphenyl-2H-imidazole-2-thione
2H-Imidazole-2-thione, 1,3-dihydro-1,4-diphenyl- | [Molecular Formula]
C15H12N2S | [MDL Number]
MFCD02712628 | [MOL File]
79220-94-3.mol | [Molecular Weight]
252.33 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble ≥20mg/mL | [form ]
powder | [color ]
light yellow to light tan | [InChI]
1S/C15H12N2S/c18-15-16-14(12-7-3-1-4-8-12)11-17(15)13-9-5-2-6-10-13/h1-11H,(H,16,18) | [InChIKey]
QKOAQVKXZJFMET-UHFFFAOYSA-N | [SMILES]
S=C1NC(=CN1c2ccccc2)c3ccccc3 |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H319 | [Precautionary statements ]
P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
36 | [Safety Statements ]
26 | [WGK Germany ]
WGK 3 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Uses]
KRM-III is a potent and orally active T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of ~5 μM. Anti-inflammatory activity[1]. | [Biological Activity]
KRM-III is an inhibitor of T cell antigen receptor (TCR)an inhibitor of phorbol myristate acetate (PMA) /ionomycin-induced nuclear factor of activated T cells (NFAT) activation and T cell proliferation. | [References]
[1] Eun Joo Jung, et al. Oral administration of 1,4-aryl-2-mercaptoimidazole inhibits T-cell proliferation and reduces clinical severity in the murine experimental autoimmune encephalomyelitis model. J Pharmacol Exp Ther. 2009 Dec;331(3):1005-13. DOI:10.1124/jpet.109.154948 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
MedChemExpress
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| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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