| Identification | Back Directory | [Name]
Adenosine 5′-(tetrahydrogen triphosphate), 8-chloro-, tetrasodium salt | [CAS]
793671-47-3 | [Synonyms]
8-Chloroadenosine-5'-triphosphate sodium
8-Chloroadenosine-5'-triphosphate (sodium salt)
Adenosine 5′-(tetrahydrogen triphosphate), 8-chloro-, tetrasodium salt | [Molecular Formula]
C10H15ClN5O13P3.4Na | [Molecular Weight]
633.59 |
| Hazard Information | Back Directory | [Uses]
8-Chloro-ATP tetrasodium, an ATP (HY-B2176) analog, is a topoisomerase II (Topo II) inhibitor. 8-Chloro-ATP tetrasodium inhibits DNA synthesis and induces DNA double-stranded breaks (DSBs). 8-Chloro-ATP tetrasodium inhibits Topo II-catalyzed ATP hydrolysis[1]. | [IC 50]
Topoisomerase II | [References]
[1] Sheng-Yong Yang, et al. Inhibition of topoisomerase II by 8-chloro-adenosine triphosphate induces DNA double-stranded breaks in 8-chloro-adenosine-exposed human myelocytic leukemia K562 cells. Biochem Pharmacol. 2009 Feb 1;77(3):433-43. DOI:10.1016/j.bcp.2008.10.022 |
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