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79426-51-0

79426-51-0 Structure

79426-51-0 Structure
IdentificationBack Directory
[Name]

A 39183A
[CAS]

79426-51-0
[Synonyms]

A 39183A
Antibiotic A-39183A
[Molecular Formula]

C34H30O10
[MDL Number]

MFCD33021109
[MOL File]

79426-51-0.mol
[Molecular Weight]

598.6
Chemical PropertiesBack Directory
[Boiling point ]

790.1±60.0 °C(Predicted)
[density ]

1.509±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMF: soluble; DMSO: soluble; Ethanol: soluble
[form ]

A solid
[pka]

3.36±0.60(Predicted)
Hazard InformationBack Directory
[Description]

A-39183A is an active component of the A-39183 antibiotic complex produced by aerobic fermentation of Streptomyces NRRL 12049. It has activity against penicillin-resistant S. aureus 3055 and S. faecalis X66 (MICs = 32 and 32 μg/ml, respectively) and a variety of Gram-positive and Gram-negative anaerobic bacteria (MICs = 16-128 μg/ml) in an agar dilution assay.
[Uses]

A 39183A is a rare 9,9’-bianthryl antibiotic related to setomimycin isolated from a strain of Streptomyces by researchers at Eli Lilly, USA, in 1981. A 39183A has broad spectrum antibiotic activity against both susceptible and resistant isolates including many anaerobic species. The patent reported that A 38183A acts as an ionophore, aiding the partitioning of Mg+ and Ca+ ions into organic solvents and transport of ferric ions into mitochondria.
[storage]

Store at -20°C
[References]

[1] 5194381 Feline interferon and process for production thereof[J]. Biotechnology advances, 1994, 12 1: Page 116. DOI: 10.1016/0734-9750(94)90352-2
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