| Identification | Back Directory | [Name]
DM3-Sme | [CAS]
796073-70-6 | [Synonyms]
DM3-Sme
Maytansine, N2'-deacetyl-N2'-[4-(methyldithio)-1-oxopentyl]- (9CI) | [Molecular Formula]
C38H54ClN3O10S2 | [MDL Number]
MFCD28400103 | [MOL File]
796073-70-6.mol | [Molecular Weight]
812.43 |
| Chemical Properties | Back Directory | [Boiling point ]
962.6±65.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
9.82±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2]. | [Uses]
DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2]. | [IC 50]
Maytansinoids | [storage]
Store at -20°C | [References]
[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).
[2]. Yuliang Zhaoet al. Biomedical Nanomaterials. 2016-Science. |
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