| Identification | Back Directory | [Name]
5H-1,3,4-Thiadiazolo[3,2-a]pyrimidin-5-one, 2-ethyl-7-(1-piperazinyl)- | [CAS]
796886-30-1 | [Synonyms]
RUC1
RUC-1
RUC 1
5H-1,3,4-Thiadiazolo[3,2-a]pyrimidin-5-one, 2-ethyl-7-(1-piperazinyl)- | [Molecular Formula]
C11H15N5OS | [MOL File]
796886-30-1.mol | [Molecular Weight]
265.33 |
| Hazard Information | Back Directory | [Description]
RUC-1 is a αIIbβ3-selective inhibitor of adenosine-5'-diphosphate (ADP) -induced platelet aggregation. | [Uses]
RUC-1 (Compound 1) is an inhibitor for αIIbβ3 integrin. RUC-1 inhibits fibrin deposition and platelet aggregation in hybrid hαIIb/mβ3 receptors expressing mice. RUC-1 exhibits antithrombotic effect in hαIIb/mβ3 receptor expressing mice[1]. | [References]
[1] Blue R, et al., Structural and therapeutic insights from the species specificity and in vivo antithrombotic activity of a novel alphaIIb-specific alphaIIbbeta3 antagonist. Blood. 2009 Jul 2;114(1):195-201. DOI:10.1182/blood-2008-08-169243 |
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