| Identification | Back Directory | [Name]
LCH-7749944 | [CAS]
796888-12-5 | [Synonyms]
LCH-7749944
GNF-PF-2356
LCH-7749944， GNF-PF-2356
2,4-Quinazolinediamine, N2-(3-methoxyphenyl)-N4-[(tetrahydro-2-furanyl)methyl]- | [Molecular Formula]
C20H22N4O2 | [MOL File]
796888-12-5.mol | [Molecular Weight]
350.41 |
| Chemical Properties | Back Directory | [Boiling point ]
580.0±58.0 °C(Predicted) | [density ]
1.272±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO: 250 mg/mL (713.45 mM) | [form ]
Solid | [pka]
7.68±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor with an IC50 of 14.93 μM. LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis[1]. | [IC 50]
PAK4: 14.93 μM (IC50) | [References]
[1] Zhang J, et al. LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. Cancer Lett. 2012 Apr 1;317(1):24-32. DOI:10.1016/j.canlet.2011.11.007 |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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