| Identification | Back Directory | [Name]
Dopropidil | [CAS]
79700-61-1 | [Synonyms]
4205CERM
Dopropidil
Pyrrolidine, 1-[1-[(2-methylpropoxy)methyl]-2-[[1-(1-propyn-1-yl)cyclohexyl]oxy]ethyl]- | [Molecular Formula]
C20H35NO2 | [MDL Number]
MFCD00868990 | [MOL File]
79700-61-1.mol | [Molecular Weight]
321.5 |
| Hazard Information | Back Directory | [Uses]
Dopropidil is a novel anti-anginal calcium ion modulating agent, possessing intracellular calcium antagonist activity and
anti-ischemic effects in several predictive animal models. | [in vivo]
Dopropidil (1 and 2.5 mg/kg) dose-dependently reduces the electrical (ST segment elevation), biochemical (lactate production and potassium release), and mechanical (loss in myocardial segment contractility) perturbations induced by ischemia in the anesthetized dog. Intraduodenal administration of Dopropidil (50 mg/kg) significantly reduces isoproterenol-induced tachycardia. This effect is manifest at 15-120 min following administration of the compound which indicates a rapid absorption and a long duration of action. In conscious dogs Dopropidil (12-14 mg/kg p.o.) reduces resting heart rate by approximately10 beats/min[1]. | [storage]
Store at -20°C | [References]
[1] J. Planellas, et al. Dopropidil, A Novel Antianginal Calcium Modulating Agent. Cardiovascular Drug Reviews. Vol.12, No.3, pp. 208-224. |
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