| Identification | Back Directory | [Name]
Sodium theophylline glycinate | [CAS]
8000-10-0 | [Synonyms]
Sodium theophylline glycinate
THEOPHYLLINE SODIUM GLYCINATE USP/EP/BP
Sodium theophylline glycinate USP/EP/BP
Sodium 2-aminoacetate 1,3-dimethyl-7H-purine-2,6-dione | [EINECS(EC#)]
200-110-4 | [Molecular Formula]
C9H12N5NaO4 | [MOL File]
8000-10-0.mol | [Molecular Weight]
277.21 |
| Hazard Information | Back Directory | [Uses]
Theophylline (1,3-Dimethylxanthine) sodium glycinate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline sodium glycinate inhibits PDE3 activity to relax airway smooth muscle. Theophylline sodium glycinate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline sodium glycinate induces apoptosis. Theophylline sodium glycinate can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5]. | [in vivo]
Theophylline sodium glycinate (100 mg/kg; i.p.; daily, for 9 d) has anti-inflammatory activity in mice and increases IL-6 and IL-10 levels and inhibits TNF-α and NO in male Swiss mice[1].
| Animal Model: | Male Swiss mice[1] | | Dosage: | 100 mg/kg | | Administration: | Intraperitoneal injection; daily; for 9 days | | Result: | Increased IL-6 and IL-10 levels and inhibited TNF-α and NO. |
| [IC 50]
IL-10; IL-6 | [References]
[1] Rabe KF, et, al. Theophylline and selective PDE inhibitors as bronchodilators and smooth muscle relaxants. Eur Respir J. 1995 Apr;8(4):637-42. PMID:7664866
[2] Németh ZH, et, al. Amrinone and theophylline differentially regulate cytokine and nitric oxide production in endotoxemic mice. Shock. 1997 May;7(5):371-5. DOI:10.1097/00024382-199705000-00010
[3] Ito K, et, al, Adcock IM, Barnes PJ. A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8921-6. DOI:10.1073/pnas.132556899
[4] Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013 Oct 15;188(8):901-6. DOI:10.1164/rccm.201302-0388PP |
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