| Identification | Back Directory | [Name]
KLD12 | [CAS]
800379-47-9 | [Synonyms]
KLD12
L-Leucinamide, N2-acetyl-L-lysyl-L-leucyl-L-α-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl-L-leucyl-L-lysyl-L-leucyl-L-α-aspartyl- | [Molecular Formula]
C68H122N16O19 | [MOL File]
800379-47-9.mol | [Molecular Weight]
1467.82 |
| Chemical Properties | Back Directory | [Boiling point ]
1683.9±65.0 °C(Predicted) | [density ]
1.198±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.20±0.10(Predicted) | [color ]
White to off-white | [Sequence]
Ac-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-Lys-Leu-Asp-Leu-NH2 |
| Hazard Information | Back Directory | [Uses]
KLD-12 is a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair[1][2][3]. | [in vivo]
KLD-12 (10-250 μg/rat, single dose, injection to infracture site) promotes bone regeneration at the fracture site in a dose-dependent manner in Sprague-Dawley rats model with drill-hole injury in femur[2]. | Animal Model: | Sprague-Dawley rats model with drill-hole injury in femur[2] | | Dosage: | 10-250 μg/rat | | Administration: | injection to the fracture site, single dose | | Result: | Increased osteoinduction and callus formation. |
| [References]
[1] Cao M, et al., Self-Assembled KLD-12/SDF-1 Polypeptide Promotes Differentiation and Migration of BMSCs?via?the Wnt/β-catenin Signaling Pathways. Protein Pept Lett. 2022;29(10):851-858. DOI:10.2174/0929866529666220822124627
[2] Tripathi JK, et al., Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties. Biomaterials. 2015 Jul;56:92-103. DOI:10.1016/j.biomaterials.2015.03.046
[3] Kisiday J, Jet al., Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9996-10001. DOI:10.1073/pnas.142309999 |
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