| Identification | Back Directory | [Name]
BroModifluoroMethyl phenyl sulfone | [CAS]
80351-58-2 | [Synonyms]
BroModifluoroMethyl phenyl sulfone
Bromodifluoromethanesulfonylbenzene
[(bromodifluoromethyl)sulfonyl]benzene
Benzene, [(bromodifluoromethyl)sulfonyl]- | [Molecular Formula]
C7H5BrF2O2S | [MDL Number]
MFCD22628354 | [MOL File]
80351-58-2.mol | [Molecular Weight]
271.08 |
| Chemical Properties | Back Directory | [Melting point ]
33-34 °C | [Boiling point ]
291.8±40.0 °C(Predicted) | [density ]
1.745±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Sparingly), DMSO (Slightly) | [form ]
Solid | [color ]
White to Off-White | [InChI]
InChI=1S/C7H5BrF2O2S/c8-7(9,10)13(11,12)6-4-2-1-3-5-6/h1-5H | [InChIKey]
VYNTWHUALGNGNU-UHFFFAOYSA-N | [SMILES]
C1(S(C(Br)(F)F)(=O)=O)=CC=CC=C1 |
| Hazard Information | Back Directory | [Description]
The nucleophilic reactions of bromodifluoromethyl phenyl sulfone with electrophiles such as
aldehydes in the presence of TDAE affords (phenylsulfonyl)difluoromethyl-containing
synthetically useful intermediates. Palladium-mediated reactions of styrene derivatives, vinyl
ethers, and heteroaromatics with bromodifluoromethyl phenyl sulfone in the presence of
potassium carbonate affords the (phenylsulfonyl)difluoromethylated products. | [Uses]
Bromodifluoromethyl Phenyl Sulfone can be used to prepare difluoromethyl ethers via difluoromethylation of alcohols. | [Uses]
Bromodifluoromethyl phenyl sulfone is an intermediate component in the synthesis of (phenylsulfonyl)difluoromethyl and can be used to prepare (phenylsulfonyl)difluoromethylated products by palladium-mediated reactions. | [Reactions]
(1) Difluoromethylation of aldehydes.
(2) Difluoromethylation of styrenes, vinyl ethers, and heteroaromatics.
| [References]
[1] G.K. SURYA PRAKASH . Nucleophilic difluoromethylation and difluoromethylenation using bromodifluoromethyl phenyl sulfone[J]. Journal of Fluorine Chemistry, 2005. DOI:10.1016/j.jfluchem.2005.07.011.
[2] NAKIN SURAPANICH. ChemInform Abstract: Palladium-Mediated Heck-Type Reactions of [(Bromodifluoromethyl)sulfonyl]benzene: Synthesis of α-Alkenyl- and α-Heteroaryl-Substituted α,α-Difluoromethyl Phenyl Sulfones.[J]. ChemInform, 2013. DOI:10.1002/chin.201314090.
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| Company Name: |
SHANG FLUORO Gold
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| Tel: |
021-65170832 15601903708 |
| Website: |
http://www.shangfluoro.com |
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