| Identification | Back Directory | [Name]
oxanosine | [CAS]
80394-72-5 | [Synonyms]
oxanosine
1-Oxaguanosine
5-Amino-3-β-D-ribofuranosylimidazo[4,5-d][1,3]oxazin-7(3H)-one
Imidazo[4,5-d][1,3]oxazin-7(3H)-one, 5-amino-3-β-D-ribofuranosyl- | [Molecular Formula]
C10H12N4O6 | [MDL Number]
MFCD01720542 | [MOL File]
80394-72-5.mol | [Molecular Weight]
284.23 |
| Chemical Properties | Back Directory | [Melting point ]
199 °C(Solv: water (7732-18-5)) | [Boiling point ]
758.1±70.0 °C(Predicted) | [density ]
2.23±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
A solid | [pka]
13.17±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Oxanosine is an antibiotic isolated from the streptomyces MG265-CF34, which has anti-tumor activity. Oxanosine is also a substrate for adenosine deaminase[1][2]. | [storage]
-20°C | [References]
[1] Runhan Yu, et al. Oxanosine monophosphate is a covalent inhibitor of inosine 5’-monophosphate dehydrogenase. Chem Res Toxicol. 2019 Feb 25;32(3):456–466.
[2] Papiya Majumdar, et al. Oxanosine is a substrate of adenosine deaminase. Implications for the quest for a toxicological marker for nitrosation activity. Chem Res Toxicol. 2005 Dec;18(12):1830-41. DOI:10.1021/tx050232h |
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