| Identification | Back Directory | [Name]
20-CARBOXY-LEUKOTRIENE B4 | [CAS]
80434-82-8 | [Synonyms]
20-COOH-LTB4
20-CARBOXY-LEUKOTRIENE B4
20-hydroxy-20-oxoleukotriene B4
5S,12R-DIHYDROXY-6Z,8E,10E,14Z-EICOSATETRAENE-1,20-DIOIC ACID
(5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenedioic acid
6,8,10,14-Eicosatetraenedioic acid, 5,12-dihydroxy-, (5S,6Z,8E,10E,12R,14Z)- | [Molecular Formula]
C20H30O6 | [MDL Number]
MFCD00065857 | [MOL File]
80434-82-8.mol | [Molecular Weight]
366.45 |
| Chemical Properties | Back Directory | [Boiling point ]
588.3±50.0 °C(Predicted) | [density ]
1.151±0.06 g/cm3(Predicted) | [Fp ]
14℃ | [storage temp. ]
−20°C | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml | [form ]
Liquid | [pka]
4.66±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. The resulting 20-hydroxy LTB4 is further oxidized to 20-carboxy LTB4. LTB4 metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB4 along with other ω-oxidation products. The biological activity of 20-carboxy LTB4 is only about 2.6% compared to that of LTB4 in causing PMNL degranulation. | [Uses]
20-COOH-LTB4 is a leukotriene B4 metabolite and substrate for β-oxidation pathways. | [Definition]
ChEBI: A member of the class of leukotrienes that is leukotriene B4 in which the terminal methyl group has undergone formal oxidation to the corresponding carboxylic acid. | [IC 50]
Human Endogenous Metabolite; BLT1 | [References]
[1] G?RAN HANSSON . Identification and biological activity of novel ω-oxidized metabolites of leukotriene B4 from human leukocytes[J]. FEBS Letters, 1981, 130 1: Pages 107-112. DOI: 10.1016/0014-5793(81)80676-x
[2] T. HARPER R M M Garrity. Metabolism of leukotriene B4 in isolated rat hepatocytes. Identification of a novel 18-carboxy-19,20-dinor leukotriene B4 metabolite.[J]. The Journal of Biological Chemistry, 1986, 140 1: 5414-5418. DOI: 10.1016/s0021-9258(19)57231-3
[3] STEVEN J. FEINMARK. Stimulation of human leukocyte degranulation by leukotriene B4 and its ω-oxidized metabolites[J]. FEBS Letters, 1981, 136 1: Pages 141-144. DOI: 10.1016/0014-5793(81)81233-1 |
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