| Identification | Back Directory | [Name]
TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-TRP-ASP-ASN-GLN-NH2 | [CAS]
80448-90-4 | [Synonyms]
DYNORPHIN A
dynorphin-(1-17)
Dynorphin A【pig】
Dynorphin A【rat】
DYNORPHIN A AMIDE
YGGFLRRIRPKLKWDNQ
Dynorphin acetate
Dynorphins(1 - 17)
DYNORPHIN A (1-17)
DYNORPHIN A(HUMAN)
Dynorphin A (swine)
DYNORPHIN A PORCINE
PRODYNORPHIN (209-225)
DYNORPHIN A AMIDE, PORCINE
Dynorphin A (human, porcine)
PRODYNORPHIN (207-223) (HUMAN)
PRODYNORPHIN (209-225) (PORCINE)
Dynorphin (1-17), Dynorphin (1-13)
DYNORPHIN A PRODYNORPHIN (207-223), HUMAN
DYNORPHIN A (HUMAN) (PORCINE, RAT, BOVINE)
Dynorphin A (1-17), (Prodynorphin 209-225), Porcine
Prodynorphin (207-223) (huMan), Prodynorphin (209-225) (porcine)
TRY-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-TRP-ASP-ASN-GLN
TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-TRP-ASP-ASN-GLN
TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-TRP-ASP-ASN-GLN-NH2
H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-TRP-ASP-ASN-GLN-OH
L-Tyr-Gly-Gly-L-Phe-L-Leu-L-Arg-L-Arg-L-Ile-L-Arg-L-Pro-L-Lys-L-Leu-L-Lys-L-Trp-L-Asp-L-Asn-L-Gln-OH | [Molecular Formula]
C99H155N31O23 | [MDL Number]
MFCD00079857 | [MOL File]
80448-90-4.mol | [Molecular Weight]
2147.51 |
| Chemical Properties | Back Directory | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Soluble to 0.80 mg/ml in water | [Sequence]
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln | [InChIKey]
JMNJYGMAUMANNW-FIXZTSJVSA-N |
| Hazard Information | Back Directory | [Uses]
Dynorphin A has been used in immunohistochemistry. | [Biochem/physiol Actions]
Dynorphin A porcine is an opioid peptide. It is an endogenous κ-agonist that is resistant to enzymatic degradation. Dynorphin A has the ability to decrease calcium current by selectively decreasing the large inactivating (N) calcium current. It can decrease the calcium-dependent action potential duration of DRG (dorsal root ganglion) and myenteric neurons. | [in vivo]
Dynorphin A (intracerebroventricular injection, 1 μg of 2 μL, a single dose) inhibits vasopressin (VP) release in 24 h water-deprived male rats[5].
Dynorphin A (intracerebroventricular injection, 500 pmol/5 μL per day for 4 d) alleviates stress-induced behavioral impairments in ddY mice accompanied by regulation of the 5-HTergic system in the brain[6]. | Animal Model: | 24 h water-deprived male rats[5] | | Dosage: | 1 μg of 2 μL | | Administration: | Intracerebroventricular injection | | Result: | Inhibited vasopressin (VP) release 30 min upon injection. |
| Animal Model: | Male ddY mice[6] | | Dosage: | 15, 150, 1500 pmol/5 μL per day for 4 days | | Administration: | Intracerebroventricular injection | | Result: | Attenuated the repeated stress-induced escape failures from the shock. |
| [IC 50]
Human Endogenous Metabolite; Caspase 3; κ Opioid Receptor/KOR | [storage]
Store at -20°C |
|
| Company Name: |
Sigma-Aldrich
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| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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