| Identification | Back Directory | [Name]
Ulinastatin | [CAS]
80449-31-6 | [Synonyms]
D05183
Miraclid
ULINASTATIN
Miraclid (tn)
Ulinastatin (jp15)
Purified Ulinastatin
Trypsininhibitor, bikunin
URINASTATIN (UTI) SYN. BIKUNIN
Lyophilized Powder Peptides Peptide Follistatin 344 F344 for Bodybuilding CAS 80449-31-6 1mg/Vial | [EINECS(EC#)]
273-984-4 | [Molecular Formula]
C13H16O3 | [MDL Number]
MFCD02689240 |
| Hazard Information | Back Directory | [Uses]
Ulinastatin is a trypsin and serine protease inhibitor. It exerts its protective effects as well as stabilising lysosomes and cell membranes by inhibiting various serine proteases. Ulinastatin has neuroprotective, anti-inflammatory, anti-apoptotic, antioxidant, and anticoagulant effects. It is used in the treatment of diseases such as alcoholic pancreatitis, acute pancreatitis, sepsis, circulatory shock and systemic inflammatory response syndrome, including burns and acute respiratory distress syndrome (ARDS)[1]. | [in vivo]
Ulinastatin (10000 U/kg; i.v.; twice) significantly protects animals from LPS-induced acute lung injury (ALI), decreasing the lung wet/dry weight ratio, ALI score, total cells, neutrophils, macrophages, myeloperoxidase activity, and malondialdehyde content, factors associated with lung histological damage[1]. | Animal Model: | Male C57BL/6 mice (8-10 weeks old, 18-22 g)[1] | | Dosage: | 10000 U/kg | | Administration: | i.v.; twice (1 h before and 6 h after LPS treatment) | | Result: | Significantly protected animals from LPS-induced ALI. |
| [References]
[1] WEN-TAO MENG. Ulinastatin: A Potential Alternative to Glucocorticoid in the Treatment of Severe Decompression Sickness.[J]. Frontiers in Physiology, 2020: 273. DOI:10.3389/fphys.2020.00273. |
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