| Identification | Back Directory | [Name]
8-Oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a][1,3]diazepine-3-carboxylicacidmethyl ester | [CAS]
805326-00-5 | [Synonyms]
HIE-124
HIE124,HIE 124
8-Oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a][1,3]diazepine-3-carboxylicacidmethyl ester
Thiazolo[3,2-a][1,3]diazepine-3-carboxylic acid, 5,6,7,8-tetrahydro-8-oxo-, ethyl ester | [Molecular Formula]
C10H12N2O3S | [MDL Number]
MFCD28405676 | [MOL File]
805326-00-5.mol | [Molecular Weight]
240.28 |
| Hazard Information | Back Directory | [Uses]
HIE-124 is a potent ultra-short acting hypnotic that exhibits a rapid onset of action and a shorter duration of action with no acute tolerance or noticeable side effects. HIE-124 is promising for research of preanesthetic medication and anesthesia inducer[1]. | [References]
[1] Taghizadeh M J, et al. Synthesis and docking study on thiadiazolo [3, 2-a][1, 3] diazepin-8 (5H)-one derivatives as selective GABA (A) agonists[J]. Journal of Pharmaceutical & Health Sciences, 2016, 4(2): 101-108.
[2] El-Subbagh HI, et al. New ultra-short acting hypnotic: synthesis, biological evaluation, and metabolic profile of ethyl 8-oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a][1,3]diazepin-3-carboxylate (HIE-124). Bioorg Med Chem Lett. 2008 Jan 1;18(1):72-7. DOI:10.1016/j.bmcl.2007.11.011 |
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