| Identification | Back Directory | [Name]
(+/-)-6-CHLORO-7,8-DIHYDROXY-3-ALLYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE | [CAS]
80751-65-1 | [Synonyms]
Cl-apb
Chloro-AP
SK&F 82958
SKF82958 HBr
SKF82958,SKF 82958
6H-Benzo[cd]pyren-7-one
(±)-SKF 82958;CHLORO-APB
(+/-)-SKF-82958 HYDROBROMIDE
(+/-)-Chloro-apbhydrobromide
(+/-)-CHLORO-APB HYDROBROMIDE
6-CHLORO-N-ALLYL-SKF-38393 HYDROBROMIDE
(+/-)-CHLORO-APB HYDROBROMIDE ((+/-)-SKF -82958 HBR)
3-allyl-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol
6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
6-Chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-1H-3-benzazepine-7,8-diol
1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-
1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-
(+/-)-6-CHLORO-7,8-DIHYDROXY-3-ALLYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
(+/-)-6-CHLORO-7,8-DIHYDROXY-3-ALLYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROBROMIDE
(±)-SKF-82958 hydrobromide, 6-Chloro-N-allyl-SKF-38393 hydrobromide, (±)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide | [Molecular Formula]
C19H20ClNO2 | [MDL Number]
MFCD00069235 | [MOL File]
80751-65-1.mol | [Molecular Weight]
329.82 |
| Chemical Properties | Back Directory | [Boiling point ]
473.7±45.0 °C(Predicted) | [density ]
1.234±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
H2O: 3.7 mg/mL | [form ]
solid | [pka]
8.73±0.40(Predicted) | [color ]
tan | [Water Solubility ]
H2O: 3.7mg/mL
aqueous base: unstable
ethanol: soluble | [InChI]
1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H | [InChIKey]
WLXGFAVTAAQOFH-UHFFFAOYSA-N | [SMILES]
Br.Oc1cc2C(CN(CCc2c(Cl)c1O)CC=C)c3ccccc3 |
| Hazard Information | Back Directory | [Uses]
Chloro-APB hydrobromide has been used to pharmacologically stimulate D1 dopamine receptors and study its influence on locomotor response in fat mass and obesity-associated protein (FTO) deficient dopamine D1 receptor-expressing medium spiny neurons (D1 MSNs) of mice. | [Definition]
ChEBI: 9-chloro-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol is a benzazepine. | [Biochem/physiol Actions]
Chloro-APB hydrobromide, also known as SKF 82958, is a D1 dopamine receptor agonist. D1 receptor agonists prevent and reverse fentanyl-induced respiratory depression, without impairing opioid analgesia, in cats. | [in vivo]
SKF-82958 ((±)-SKF 82958) (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 training dose 0.03 mg/kg. Increasing the dose of SKF-82958 also results in a significant reduction in response rate[2].
SKF-82958 (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements[3]. | Animal Model: | Male Sprague-Dawley rats[3] | | Dosage: | 0.5-2.0 mg/kg | | Administration: | I.p | | Result: | Significantly reduced the number of tremulous jaw movements induced by 4.0 mg/kg pilocarpine.
|
| [storage]
Store at -20°C |
|
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