| Identification | Back Directory | [Name]
IMIDAZO[1,2-A]PYRIDINE, 7-BROMO- | [CAS]
808744-34-5 | [Synonyms]
7-Bromoimidazo[1,2-a]pyri...
7-Bromoimidazo[1,2-a]pyridine
7-broMoH-iMidazo[1,2-a]pyridine
IMIDAZO[1,2-A]PYRIDINE, 7-BROMO-
7-bromoimidazo[1,2-a]pyridine HCL
7-bromoH-imidazo[1,2-a]pyridine hydrochloride | [EINECS(EC#)]
1533716-785-6 | [Molecular Formula]
C7H5BrN2 | [MDL Number]
MFCD07778353 | [MOL File]
808744-34-5.mol | [Molecular Weight]
197.03 |
| Chemical Properties | Back Directory | [Melting point ]
118-120℃ | [density ]
1.69 | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
solid | [pka]
5.15±0.50(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C7H5BrN2/c8-6-1-3-10-4-2-9-7(10)5-6/h1-5H | [InChIKey]
OASOJRLJBDCVNU-UHFFFAOYSA-N | [SMILES]
C12=NC=CN1C=CC(Br)=C2 |
| Hazard Information | Back Directory | [Synthesis]
2-Amino-4-bromopyridine (5.0 g) and 2-chloroacetaldehyde (40% aqueous, 12 mL, 2.5 eq.) were dissolved in anhydrous ethanol (50 mL) and sodium bicarbonate (4.89 g, 2.0 eq.) was added. The reaction mixture was heated to reflux for 6 hours. Upon completion of the reaction, the organic solvent was removed by vacuum rotary evaporation. The residue was extracted with ethyl acetate (60 mL) and washed sequentially with water and saturated saline. The organic layer was dried with anhydrous sodium sulfate, filtered and purified by silica gel column chromatography to afford 7-bromoimidazo[1,2-a]pyridine (4.38 g, 78% yield) as a brown solid. | [References]
[1] Patent: CN106496222, 2017, A. Location in patent: Paragraph 0095; 0097
[2] Patent: WO2008/124323, 2008, A1. Location in patent: Page/Page column 68
[3] Patent: WO2008/121687, 2008, A2. Location in patent: Page/Page column 53
[4] Patent: WO2017/144633, 2017, A1. Location in patent: Page/Page column 101; 102
[5] Patent: WO2017/144639, 2017, A1. Location in patent: Page/Page column 87 |
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