| Identification | Back Directory | [Name]
N-[(1R)-5-(1,1-Dimethylethyl)-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea | [CAS]
808756-71-0 | [Synonyms]
ABT-102
CHEMBL398338
ABT-102
(ABT102)
N-(5-tert-Butylindan-1-yl)-N'-(1H-indazol-4-yl)urea
1-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-3-(1H-indazol-4-yl)urea
N-[(1R)-5-(1,1-Dimethylethyl)-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea | [Molecular Formula]
C21H24N4O | [MDL Number]
MFCD13248650 | [MOL File]
808756-71-0.mol | [Molecular Weight]
348.441 |
| Hazard Information | Back Directory | [Uses]
ABT-102 is a potent and highly selective Vanilloid Receptor (TRPV1) receptor antagonist. ABT-102 potently and reversibly increases heat pain thresholds and reduced painfulness of suprathreshold oral/cutaneous heat. ABT-102 reduces nociceptive responses of animals in models of inflammatory, bone cancer, postoperative, and osteoarthritic pain[1][2]. | [IC 50]
TRPV1 | [References]
[1] Lukin K, et al. Development of a Large Scale Asymmetric Synthesis of Vanilloid Receptor (TRPV1) Antagonist ABT-102. Organic Process Research & Development, 2007, 11(3):578-584.
[2] Rowbotham MC, et al. Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial. Pain. 2011 May;152(5):1192-1200. DOI:10.1016/j.pain.2011.01.051 |
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