| Identification | Back Directory | [Name]
2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT | [CAS]
80902-29-0 | [Synonyms]
Rp-dGTPαS
RP-DGTP-ALPHA-S SODIUM SALT
SP-DGTP-ALPHA-S SODIUM SALT
dGTPαS (Rp isomer) 100mM Sodium Solution
Rp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) (sodium salt)
Rp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) (sodium salt)
2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT
2'-DEOXYGUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), SP-ISOMER SODIUM SALT
2’-deoxyguanosine-5’-o-(1-thiotriphosphate),rpisomer(rp-dgtp-alpha-s),sodiumsalt
Guanosine, 2′-deoxy-, 5′→P′′-ester with [P′′(R)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH))
Guanosine, 2'-deoxy-, 5'→P''-ester with [P''(R)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)) (9CI) | [Molecular Formula]
C10H12N5Na4O12P3S | [MDL Number]
MFCD04118046 | [MOL File]
80902-29-0.mol | [Molecular Weight]
611.17 |
| Hazard Information | Back Directory | [Uses]
Rp-dGTPαS is the nucleotide substrate of SAMHD1 and is one of the enantiomers of the dNTPαS nucleotide. SAMHD1 is an essential regulator of cellular dNTPs that limits virus (HIV-1, etc.) replication in the CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex catalyzes the hydrolysis of Rp-dGTPαS into 2'-deoxynucleosides and triphosphates[1]. | [References]
[1] Morris ER, et al. Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers. Biochemistry. 2021 Jun 1;60(21):1682-1698. DOI:10.1021/acs.biochem.0c00944 |
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