| Identification | Back Directory | [Name]
5-fluoropyrimidin-4-amine | [CAS]
811450-26-7 | [Synonyms]
5-fluoropyrimidin-4-amine
4-Amino-5-fluoropyrimidine
4-Pyrimidinamine, 5-fluoro-
5-Fluoro-pyrimidin-4-ylamine
5-fluoropyrimidin-4-amine analogue
5-fluoropyrimidin-4-amine ISO 9001：2015 REACH | [Molecular Formula]
C4H4FN3 | [MDL Number]
MFCD00223685 | [MOL File]
811450-26-7.mol | [Molecular Weight]
113.09 |
| Hazard Information | Back Directory | [Synthesis]
General procedure: pre-step A Synthesis of 5-fluoro-4-pyrimidinamine
A mixture of 4-chloro-5-fluoropyrimidine (200 mg, 1.509 mmol) and ammonia (3.3 mL, 45.3 mmol) in methanol (580 μL) was placed in a microwave reactor, heated to 110 °C, and reacted for 30 min. Upon completion of the reaction, the reaction mixture was filtered and the solid product was collected and dried to give 5-fluoropyrimidin-4-amine (100 mg, 0.875 mmol, 58% yield) as a white solid. Mass spectrum (electrospray positive ion mode) m/z 114.1 ([M+H]+). | [References]
[1] Patent: US2013/345120, 2013, A1. Location in patent: Page/Page column
[2] Patent: US8901119, 2014, B2. Location in patent: Page/Page column |
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