| Identification | Back Directory | [Name]
R-(+)-DIOA | [CAS]
81166-47-4 | [Synonyms]
R(+)-Butylindazone, R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid | [Molecular Formula]
C20H24Cl2O4 | [MDL Number]
MFCD00069261 | [MOL File]
81166-47-4.mol | [Molecular Weight]
399.31 |
| Chemical Properties | Back Directory | [Melting point ]
173-174 °C | [Boiling point ]
562.2±50.0 °C(Predicted) | [density ]
1.307±0.06 g/cm3(Predicted) | [solubility ]
H2O: insoluble <0.11mg/mL | [form ]
solid | [pka]
2.80±0.10(Predicted) | [color ]
white | [Optical Rotation]
[α]27/D +18.1°, c = 0.7 in methanol(lit.) | [Water Solubility ]
H2O: insoluble <0.11mg/mL
DMSO: >20mg/mL
0.1 M HCl: insoluble
0.1 M NaOH: soluble
ethanol: soluble | [InChI]
1S/C20H24Cl2O4/c1-2-3-8-20(13-6-4-5-7-13)10-12-9-14(26-11-15(23)24)17(21)18(22)16(12)19(20)25/h9,13H,2-8,10-11H2,1H3,(H,23,24)/t20-/m0/s1 | [InChIKey]
YAWWQIFONIPBKT-FQEVSTJZSA-N | [SMILES]
CCCC[C@]1(Cc2cc(OCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3 |
| Hazard Information | Back Directory | [Uses]
R-(+)-DIOA has been used as a potassium/chloride K+-Cl- transport inhibitor to study its effects on:
- short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
- uptake of grepafloxacin by THP-1 monocytes
- the uptake of moxifloxacin by THP-1 monocytes
| [Uses]
R-(+)-DIOA is an inhibitor of the K+/Cl--cotransport that does not affect the bumetanide-Na+/K+/Cl--cotransport system. | [Biochem/physiol Actions]
[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl?)?co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system. |
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