| Identification | Back Directory | [Name]
(+/-)14,15-EPOXYEICOSA-5Z,8Z,11Z-TRIENOIC ACID | [CAS]
81276-03-1 | [Synonyms]
14,15-EET
14(15)-EPETRE
(+/-)14,15-EET
(+/-)14(15)-EPETRE
14,15-Epoxyeicosatrienoic acid
14,15-epoxy-5,8,11-eicosatrienoicacid
(+/-)14,15-EPOXYEICOSA-5Z,8Z,11Z-TRIENOIC ACID
(+/-)14(15)-EPOXY-5Z,8Z,11Z-EICOSATRIENOIC ACID
5,8,11-Tridecatrienoic acid, 13-(3-pentyl-2-oxiranyl)-
"14,15-Epoxyeicosa-5,8,11-trienoic Acid D11 (14,15-EET)"
(5Z,8Z,11Z,14R,15S)-14,15-Epoxy-5,8,11-icosatrienoic acid
(5Z,8Z,11Z)-13-(3-pentyloxiran-2-yl)trideca-5,8,11-trienoic acid
(5Z,8Z,11Z)-13-[(2R,3S)-3-Pentyloxiranyl]-5,8,11-tridecatrienoic acid | [Molecular Formula]
C20H32O3 | [MDL Number]
MFCD00132918 | [MOL File]
81276-03-1.mol | [Molecular Weight]
320.47 |
| Chemical Properties | Back Directory | [Boiling point ]
464.5±33.0 °C(Predicted) | [density ]
0.983±0.06 g/cm3(Predicted) | [Fp ]
14 °C | [storage temp. ]
−20°C | [form ]
Liquid
(Density: 0.983±0.06 g/cm3) | [pka]
4.78±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
Epoxyeicosatrienoic Acid (EET) has antihypertensive and anti-inflammatory properties and play a role in the maintenance of renal vascular function. N,?N''-?dicyclohexylurea (DCU) increased release of 14,15-EET when the cells were stimulated with a calcium ionophore.Also, it is derived from Arachidonic Acid >97% (A765000), which is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides. | [Definition]
ChEBI: 14,15-Epoxy-5,8,11-eicosatrienoic acid is a long-chain fatty acid. | [in vivo]
14,15-Epoxyeicosatrienoic acid (0.3 mg/kg i.v.) inhibits platelet aggregation in mouse cerebral arterioles[2].
14,15-Epoxyeicosatrienoic acid (200 ng/ml) infusion into the hippocampus reversed Aβ deposition in the brains of 6-month-old male FAD mice[1].
| [IC 50]
Human Endogenous Metabolite |
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