| Identification | Back Directory | [Name]
Polyprenic | [CAS]
81485-25-8 | [Synonyms]
E-5166
NIK-333
Polyprenic
POLYPRENOICACID
NIK-333;NIK333;NIK 333
4,5-Dehydrogeranylgeranoic acid
4,5-Didehydrogeranylgeranoic acid
3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid
all-trans-3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenoic acid
(2E,4E,6E,10E)-3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenoic acid
(2E,4E,6E,10E)-3,7,11,15-tetraMethyl
hexadeca-2,4,6,10,14-pentaenoic acid
2,4,6,10,14-Hexadecapentaenoicacid, 3,7,11,15-tetraMethyl-, (2E,4E,6E,10E)- | [Molecular Formula]
C20H30O2 | [MDL Number]
MFCD01742209 | [MOL File]
81485-25-8.mol | [Molecular Weight]
302.45 |
| Chemical Properties | Back Directory | [Boiling point ]
460.3±24.0 °C(Predicted) | [density ]
0.943±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Acetonitrile (Slightly, Heated), Benzene (Slightly), Chloroform (Slightly) | [form ]
Solid | [pka]
4.79±0.33(Predicted) | [color ]
Pale Brown to Orange | [InChI]
1S/C20H30O2/c1-16(2)9-6-10-17(3)11-7-12-18(4)13-8-14-19(5)15-20(21)22/h8-9,11,13-15H,6-7,10,12H2,1-5H3,(H,21,22)/b14-8+,17-11+,18-13+,19-15+ | [InChIKey]
UUBHZHZSIKRVIV-KCXSXWJSSA-N | [SMILES]
OC(=O)\C=C(/C)\C=C\C=C(\CC\C=C(\CCC=C(C)C)/C)/C |
| Hazard Information | Back Directory | [Uses]
Peretinoin is an acyclic retinoid that may have the ability to inhibit hepatic carcinogenesis | [Biological Activity]
Peretinoin is an orally active synthetic acyclic retinoid (ACR) whose in vivo anti-hepatocellular carcinoma (HCC) efficacy is attributed to its upregulatory activity toward retinoid nuclear receptors (RARbeta & RXRalpha)as well as negative regulation against sphingosine kinase 1 (SPHK1) expression andtherebysphingosine metabolic pathway. Peretinoin inhibits the replication of hepatitis B & C viruses in cultures (HBV & HCV EC50 = 9-25 μM) and shows in vivo efficacy in rodent models of hepatocarcinogenesis among rats (1040or 80 mg/kg/day p.o.) and mice (0.03% or 0.06% in diet) subjected to chronic inflammation induction by diethylnitrosamine (DEN). |
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| Company Name: |
Musechem
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| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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